Clinical Significance of Cerebral Oxygenation During Exercise in Patients With Coronary Artery Disease
-
- Koike Akira
- The Cardiovascular Institute
-
- Nagayama Osamu
- The Cardiovascular Institute
-
- Hoshimoto-Iwamoto Masayo
- The Cardiovascular Institute School of Health and Sports Science, Juntendo University
-
- Suzuki Takeya
- Department of Cardiovascular Medicine, Toho University Omori Medical Center
-
- Tajima Akihiko
- The Cardiovascular Institute
-
- Uejima Tokuhisa
- The Cardiovascular Institute
-
- Aizawa Tadanori
- The Cardiovascular Institute
この論文をさがす
抄録
Background Recent investigations have demonstrated that cerebral oxyhemoglobin (O2Hb) decreases during exercise in patients with left ventricular dysfunction, reflecting a cerebral hypoxia. We sought to establish a prognostic value of decreased cerebral O2Hb during exercise in cardiac patients, and to compare it with those of indexes obtained from cardiopulmonary exercise testing (CPX). Methods and Results A total of 344 consecutive patients with coronary artery disease were enrolled in the study. All the patients performed CPX, during which cerebral O2Hb was continuously monitored using near-infrared spectroscopy. There were 13 cardiac deaths and 78 cardiovascular events during the prospective follow-up period of 1,231±538 days. The change of O2Hb measured at the forehead from rest to peak exercise (ΔO2Hb) was significantly lower in non-survivors than in survivors (-1.5±3.3 vs 1.7±3.2 μmol/L, p=0.0004). By multivariate Cox proportional hazards analysis, ΔO2Hb and left ventricular ejection fraction (LVEF) were found to be independent prognostic markers for cardiac deaths. The ΔO2Hb, LVEF and peak oxygen uptake were found to be significant prognostic markers for cardiovascular events, mainly for heart failure worsening and sudden cardiac death. Conclusion The present findings suggest that a decrease in cerebral O2Hb during exercise predicts future cardiovascular events in patients with coronary artery disease. (Circ J 2008; 72: 1852 - 1858)<br>
収録刊行物
-
- Circulation Journal
-
Circulation Journal 72 (11), 1852-1858, 2008
一般社団法人 日本循環器学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680079891584
-
- NII論文ID
- 110006975579
-
- NII書誌ID
- AA11591968
-
- ISSN
- 13474820
- 13469843
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可