Fast Repair Activities Towards dGMP Hydroxyl Radical Adducts by Silybin and its Analogues
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- FU Haiying
- Nuclear Professional School, School of Engineering, The University of Tokyo
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- KATSUMURA Yosuke
- Advanced Science Research Center, Japan Atomic Energy Agency Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo
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- LIN Mingzhang
- Advanced Science Research Center, Japan Atomic Energy Agency
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- HATA Kuniki
- Nuclear Professional School, School of Engineering, The University of Tokyo
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- MUROYA Yusa
- Nuclear Professional School, School of Engineering, The University of Tokyo
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- HATANO Yoshihiko
- Advanced Science Research Center, Japan Atomic Energy Agency
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抄録
The repair activities of silybin (SLB) and its analogues towards the oxidizing deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts are investigated by pulse radiolytic techniques. On pulse irradiation of nitrous oxide saturated 2.0 mM dGMP aqueous solution containing 0.1 mM silybin at neutral pH, the transient absorption spectrum of the dGMP hydroxyl radical adducts decreases with the formation of the phenoxyl radical of silybin within tens of microseconds, indicating that there is a repair reaction between the dGMP hydroxyl radical adduct and silybin. The rate constant of the repair reaction is calculated to be 1.0 × 109 M-1s-1 for silybin. The repair activity of hesperetin (HESP), naringin (NAN) and naringenin (NAR) towards hydroxyl radical adducts of dGMP are also studied.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 49 (6), 609-614, 2008
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680192903808
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- NII論文ID
- 110006985820
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- NII書誌ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 9710477
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可