長期間のアスタキサンチン摂取がサルコペニアに及ぼす影響  [in Japanese] EFFECT OF LONG-TERM DIETARY ASTAXANTHIN INTAKE ON SARCOPENIA  [in Japanese]

Oxidative stress is thought to be a significant contributing factor of age-related sarcopenia. We tested the hypothesis that long-term dietary antioxidant (astaxanthin) intake attenuates sarcopenia. Wistar strain male rats, aged 45 weeks old, were given either control (Cont) or astaxanthin feed (0.004%, Ax) for 1 year. The soleus muscle weight and muscle weight-to-body weight ratios in Ax group were significantly higher than in Cont group, but tibialis anterior muscle mass was similar between the two dietary groups. The level of ubiquitinated proteins was significantly lower in the soleus muscles of Ax group, but not in tibialis anterior muscles when compared with Cont group. Tibialis anterior levels of cathepsin L, especially, and caspase-3 tended to be lower in Ax group than in Cent group. Cathepsin L levels were significantly lower. Whereas no differences between Cont and Ax were observed in soleus levels. There were no significant differences in Ax supplementation on calpain 1 and 2, UBC3B, Cu/Zn SOD and nitrotyrosine levels in either soleus or tibialis anterior muscles. Our data suggest that long-term dietary astaxanthin intake attenuates age-related muscle atrophy, due in part, to reduction in ubiquitination of myofibrillar protein in slow soleus muscles, but not in fast tibialis anterior muscles.