Aqueous Extract of Kotahla Himbutu (Salacia reticulata) Stems Promotes Oxygen Comsumption and Supresses Body Fat Accumulation in Mice

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著者

    • SHIMIZU Jun
    • Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University
    • WADA Masahiro
    • Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

抄録

Kothala himbutu (KT) is a traditional medicinal plant used in treating diabetes in Ayurvedic medicine. We investigated the effect of the aqueous extract of KT stems (KTE) on energy expenditure in normal mice. Male C57BL/6J mice (<i>n</i>=28) were divided into 4 groups depending on the type of diet they were fed for 9 weeks: normal (N) diet group (N: 13.8% energy in the form of fat), high-fat (HF) diet group (HF: 53.0% energy in the form of fat), 0.1% freeze-dried KTE (KTED)-supplemented N diet group (N+KTED), and 0.1% KTED-supplemented HF diet group (HF+KTED). KTED intake significantly reduced body weight gain in mice in the N and HF groups. Although it did not affect the plasma levels of glucose, triglyceride, and nonesterified fatty acid, KTED significantly decreased the HF diet-induced increased plasma insulin level. The epididymal and perirenal white adipose tissue (WAT) weights were significantly lower in the HF+KTED group than in the HF group. The oxygen consumption (VO<sub>2</sub>), measured by indirect calorimetry, of the mice in the KTED-supplemented groups was significantly higher than that of the mice in the N and HF control groups. Moreover, KTED significantly reduced the size of epididymal WAT adipocytes in the N and HF groups. Thus, KTED promoted VO<sub>2</sub> and suppressed WAT accumulation in the mice on the N and HF diets. Therefore, KTE is beneficial in reducing N diet- and HF diet-induced obesity, which may be partly attributable to the stimulation of whole body energy metabolism.

収録刊行物

  • Journal of health science

    Journal of health science 54(6), 645-653, 2008-12-01

    公益社団法人日本薬学会

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各種コード

  • NII論文ID(NAID)
    110007005217
  • NII書誌ID(NCID)
    AA11316464
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13449702
  • NDL 記事登録ID
    9715575
  • NDL 雑誌分類
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL 請求記号
    Z54-J464
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS  J-STAGE 
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