Preparation and Prodrug Studies of Quercetin Pentabenzensulfonate

    • PENG You
    • State Key Laboratory of Food Science and Technology, Nanchang University:Department of Chemistry and Engineering, Jiujiang University
    • DENG Zeyuan
    • State Key Laboratory of Food Science and Technology, Nanchang University
    • WANG Chunfeng
    • Department of Chemistry and Engineering, Jiujiang University

Abstract

Pentabenzensulfonate (QPBS), a potential prodrug for quercetin, was designed and synthesized in high yield. It possesses better physical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kinetics than its original form. The LogP value (2.04) and the half-life of the hydrolysis value (3.85h) show that oral bioavailability is improved evidently compared with that of quercetin. These results indicate that QPBS can be considered as a potential prodrug for quercetin.

Journal

Journal of the Pharmaceutical Society of Japan   [List of Volumes]

Journal of the Pharmaceutical Society of Japan 128(12), 1845-1849, 2008-12-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  15

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Codes

  • NII Article ID (NAID) :
    110007005968
  • NII NACSIS-CAT ID (NCID) :
    AN00284903
  • Text Lang :
    ENG
  • Article Type :
    ART
  • ISSN :
    00316903
  • NDL Article ID :
    9732949
  • NDL Source Classification :
    ZS51(科学技術--薬学)
  • NDL Call No. :
    Z19-411
  • DOI :
    10.1248/yakushi.128.1845
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE