Effects of Sesquiterpene Lactones on Melanogenesis in Mouse B16 Melanoma Cells

• Ohguchi Kenji

  Gifu International Institute of Biotechnology

• Ito Masaaki

  Pola Chemical Industries, Inc.

• Yokoyama Kouji

  Pola Chemical Industries, Inc.

• Iinuma Munekazu

  Gifu Pharmaceutical University

• Itoh Tomohiro

  Gifu International Institute of Biotechnology

• Nozawa Yoshinori

  Gifu International Institute of Biotechnology

• Akao Yukihiro

  Gifu International Institute of Biotechnology

抄録

In this study, we examined the effect of sesquiterpene lactones isolated from Calea urticifolia and Tanacetum parthenium (feverfew) on melanogenesis in mouse B16 melanoma cells. In response to 3-isobutyl-1-methylxanthin (IBMX), B16 melanoma cells underwent differentiation characterized by increased melanin biosynthesis. Treatment of sesquiterpene lactones at lower concentration (1 μM) significantly blocked IBMX-induced melanogenesis, but did not induce the inhibitory activity of cell growth. Among them, 2,3-epoxyjuanislamin exhibited a potent inhibitory effect on melanogenesis. Treatment of B16 cells with 2,3-epoxyjuanislamin elicited significant decreases in tyrosinase protein and mRNA levels. These results demonstrated that the inhibitory effects of sesquiterpene lactones on melanin biosynthesis may be due to the suppression of tyrosinase expression.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 32 (2), 308-310, 2009

  公益社団法人 日本薬学会

キーワード

• melanin
• melanogenesis
• tyrosinase
• sesquiterpene lactone

詳細情報

• CRID: 1390001204628038016
• NII論文ID: 110007042145
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.32.308
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 9775590
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9775590
• Web Site: http://www.jstage.jst.go.jp/article/bpb/32/2/32_2_308/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009160379
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可