3316 自己組織化脈管構造と結合するMEMSデバイスの開発(J26-4 マイクロメカトロニクス(3),J26 マイクロメカトロニクス)

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  • 3316 Development of MEMS device integrating the vasculature using the self-organization

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Recently, studies of positional relationships of cells are seemed to be very important for cell biology. We proposed a novel concept that self-organized vasculature integrate artificial orifices on a device. Using SIMPLE (Single Mask inclined Photo-Lithography Exposure) process, it is easy to fabricate embedded channels with orifices. Endothelial cells have a characteristic property that they organize vasculature by their selves in collagen gel. HUVEC (Human Umbilical Vein Endothelial Cells) are cultured on device for about 10 days in matrigel and artificial vasculature were immobilized on orifices by self-organized.

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