尿浸潤ニ關スル實驗的研究 : 第四編 血清抗とりぷしん量ノ消長ニ就テ  [in Japanese] An experimental study of urine-infiltration : Part 4. Influence upon the quantity of the anti-trypsin in the serum  [in Japanese]

曩ニ余ハ家兎尿ヲ家兎ノ皮下組織内ニ注射シテ所謂尿浸潤ノ状態ヲ惹起セシメタルモノニ就キ、ソノ内臓諸臓器ノ變化、血球ノ型態學上ノ變化、及ビ血球沈降速度ノ變化ヲ研究シ、此場合該動物ハ一種ノ中毒状態ニ陥レルモノナルコトヲ報告セリ。急性中毒、敗血症、其他一般ニ化膿性炎症ノ場合ニ於テハ血清中ノ抗とりぷしん量ニ變化ヲ見ルハ周知ノ事實ナルモ、實驗的尿浸潤ニ關シテハ余ノ知レル限リニ於テハ其記載アルヲ知ラズ、ヨリテ茲ニ本實驗ヲ行ヘリ。血清中ノ抗とりぷしん反應ノ本態ニ關シテハ未ダ明カナラザルガ如キモ、該反應ノ昂進ハ癌腫、尿毒症、結核症、白血病、腎臓炎、重症貧血、其他一般ニ白血球ノ崩解ヲ來ス疾患ニ證明セラルルコトハ既ニ一般ニ承認セラルル所ニシテ、Muller und Jochoman. Kammer等ハコハ白血球増加ノ際白血球内ノ蛋白分解酵素ガ血液中ニ増加スルタメナリト謂ヒ、Rosenthalハ蛋白質ノ分解産物ナリト稱シ、Schmarz, Jobling and Petersonハ組織細胞破壊分解ノ際ニ細胞内ノリぽいーどノ遊離スル結果血液中ニりぽいーどノ増加スルタメナリト説明セルアリテ見解ノ一致ヲ缺ケルモ、Brockノ説ク如ク生體内ニ於ケル蛋自分解ヲ旺盛ナラシムルガ如キ各種ノ疾患ニ於テ抗とりぷしん作用ノ昂進ガ認メラルルコトハ事實ナリトス。

The method of investigation was as follows: (1) Ten healthy male rabbits of nearly the same weight received injections subcutaneously in their epilated and sterilized backs of 30 cubic centimetres of their own urine, which was generally acid in reaction. (2) Five rabbits were given injections of 30 cubic centimetres of their own urine filterd with Berkefeld's filter. (3) Six rab its received injections of 30 cubic centimetres of phy iological saltsolution each. Through examination by Gross-Fuld's method, it was proved that, a) The increase of anti-trypsin in the serum of the test-animals was very marked in (1) and (2) compared with that untreated healthy rabbits or in case (3). b) The quantity of the anti-trypsin begen to rise in 24 hours after the injection and reached a maximum on the fourth to the eighth day and was sometimes as much as twice that in the untreated healthy rabbits or in (3). c) There was no difference between (1) and (2) in the quantity.