SUPPRESSION OF SPONTANEOUS CARCINOGENESIS IN KERATINOCYTE-SPECIFIC PTEN-DEFICIENT MICE WITH SELECTIVE INHIBITION OF PI3K ISOFORMS
この論文をさがす
抄録
PTEN is a tumor suppressor gene that is mutated in many human sporadic cancers and in hereditary tumor susceptibility disorders such as Cowden disease. We have previously reported that keratinocyte-specific heterozygous Pten-deficient mice (K5CrePtenflox/+ mice) displayed enhanced susceptibility to carcinogenesis of the skin. Accordingly, to clarify whether the selective inhibition of phosphoinositide 3-kinase (PI3K) isoforms rescues the phenotypes of K5CrePtenflox/+ mice, we generated mice simultaneously lacking (PI3K) isoforms (p85α , p110α , p110δ or p110γ ) and Pten. Consequently, it was shown that heterozygous p110α deficiency (p110α +/−) and homozygous p110 deficiency (p110γ −/−) significantly rescued susceptibility to spontaneous carcinogenesis of the skin in K5CrePtenflox/+ mice. The present study sheds light on the possible role of p110α and p110γ in carcinogenesis of the skin ; thus providing new insights into a chemoprevention of squamous cell carcinoma.
収録刊行物
-
- 秋田医学
-
秋田医学 36 (1), 19-23, 2009-06-01
秋田医学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1050001202564566400
-
- NII論文ID
- 110007118184
-
- NII書誌ID
- AN00009294
-
- ISSN
- 03866106
-
- HANDLE
- 10295/1632
-
- NDL書誌ID
- 10362184
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB
- NDL
- CiNii Articles