各種神經節細胞みとこんどりあノ形態學的研究 : 第3編 各種神經節細胞みとこんどりあノ病的變化ニ關スル研究

長者 尚徳

In this study, mature rabbits which had been brought to the highest stages in the development of various diseases were used and the morbid changes of mitochondria in their various ganglion cells were very minutely observed. The diseases, purposefully contracted were first, acute infectious diseases caused by rabies virus, Trypanosoma gambiense, Rickettsia tsutsugamushi, Spirochaeta recurrentis, Staphylococcus pyogenes citreus, Spirochaeta ictero-haemorrhagiae, virus of small-pox, diphtheria toxin, virus of tetanus and tetanus toxin; second, experimental meningitises induced by infections viruses such as Streptococcus pyogenes, Staphylococcus pyogenes citreus, virus of small-pox, meningococcus, pneumonia diplococcus and tubercle bacilli; third, chronic poisonings by using muriatic acid morphine, lead acetate, chloric adrenalin, nitric acid strychinine and nicotine; and rice-disease, which I considered as one of B-avitaminosis. In the course of these experiments I came to believe that the original shape of mitochondria is granular, and learned that mitochondria in the morbid ganglion cells undergo changes in the following order: Ist period, mitochondria are darkly colored, increasing both in size and quantity. 2nd period, mitochondria are lightly colored, and reduce to finer sizes. 3rd period, mitochondria remarkably decrease. 4th period, mitochondria disappear. In detail, the changes of mitochondria in various ganglion cells of the morbid rabbits viere as follows: A) The case of rabbits infected by the acute infectious viruses. (1) When infected by rabies virus: Mitochondria in the pyramidal cells of the cerebral cortex, in the motor nerve cells of brain-stem and in the nerve cells of the anterior horn of the spinal cord showed the most remarkable morbid changes, changing according to the 3rd period. (2) When infected by Trypanosoma gambiense: Mitochondria in the Purkinje cells of the cerebellum, in the pyramidal cells of the motor cortex of the cerebrum, in the nerve cells of the brain-stem, hippocampus major, sympathetic ganglion and spinal ganglion underwent the remarkable change of the 2nd period. (3) When infected by Spirochaeta recurrentis: Mitochondria in the nerve cells of the sympathetic, accessory sympathetic, and spinal ganglion, in the motor nerve cells of the brain-stem, in the nerve cells of the anterior horn of the spinal cord and in the Purkinje cells of the cerebellum showed most remarkable changes according to the 2nd period. (4) When infected by Rickettsia tsutsugamushi: The changes of mitochondria in various ganglion cells all belonged to the Ist period. (5) When infected by Spirochaeta ictero-haemorrhagiae: Mitochondria in the sympathetic ganglion cells, in the motor nerve cells of the brain-stem and in the motor nerve cells of the anterior horn of the spinal cord and in the nerve cells of the hippocampus major showed remarkable changes of the 3rd period. (6) When infected by Staphylococcus pyogenes citreus: (Septicaemia) Most notable were the changes of mitochondria in the pyramidal cells of the cerebral motor cortex, in the motor nerve cells of the brain-stem and in the nerve cells of the anterior horn of the spinal cord, in the Purkinje cells of the cerebellum and in the nerve cells of the sympathetic, accessory sympathetic and spinal ganglions, which underwent changes of the 2nd period. (7) When infected by diphtheria toxin: Mitochondria in the Purkinje cells of the cerebellum and in the nerve cells of the sympathetic, accessory sympathetic and spinal ganglions changed clearly in accordance with the rule of the 3rd period. (8) When infected by virus and toxin of tetanus: Mitochondria in the nerve cells of the spinal ganglion and in the motor cells of the anterior horn of the spinal cord showed notable changes of the 3rd period. (9) When infected by virus of small-pox: Mitochondria in most ganglion cells underwent changes of the Ist period, except that those in the accessory sympathetic ganglion cells changed according to the 2nd period. B) Cases when experimental meningitises were induced by using various infectious viruses. (1) When caused by Streptococcus pyogenes: Mitochondria in all the ganglion cells, except that the nerve cells of the accessory sympathetic and spinal ganglions, showed changes of the Ist period. (2) When caused by Staphylococcus pyogenes citreus: Mitochondria in the ganglion cells of the hippocampus major, in the motor cells of the brain-stem and in the nerve cells of the anterior horn of the spinal cord, and in the Purkinje cells of the cerebellum changed most, the changes belonging to the 3rd period. (3) When caused by the virus of small-pox: The changes of mitochondria in the nerve cells of the cerebrum, cerebellum, spinal cord, accessory sympathetic ganglion and spinal ganglion were all the same belonging to the Ist period. (4) When caused by meningococcus: Mitochondria changes most remarkably in the ganglion cells of the cerebrum, of the cerebellum and in the spinal cord. Mitochondria in all the ganglion cells showed the change of the Ist period. 5) When infected by pneumonia diplococcus: Mitochondria in the pyramidal cells of the cerebral motor cortex, in the motor nerve cells of the brain-stem and in the nerve cells of the anterior horn of the spinal cordunderwent changes of the 3rd period, while those in the ganglion cells of the hippocampus major showed the change of the 2nd or 3rd period. 6) When caused by tubercle bacilli: Mitochondria in the motor nerve cells of the brain-stem and in the anterior horn of the spinal cord, in the ganglion cells of the hippocamous major and in the Purkinje cells of the cerebellum changed according to the 3rd period. C) The cases where rabbits were chronically poisoned by various drugs. (1) In the case of chronic morphinism: Mitochondria in the pyramidal cells of the cerebral motor cortex, in the motor nerve cells of the brain-stem and in the nerve cells of the anterior horn of the spinal cord, and in the ganglion cells of the hippocampus major showed the change of the 2nd period. (2) In the case of chronic lead poisoning: Mitochondria in the various ganglion cells changed equally, and according to the 3rd period. (3) In the case of adrenalin poisoning: Mitochondria in the motor nerve cells of the brain-stem and in the nerve cells of the anterior horn of the spinal cord, and in the Purkinje cells of the cerebellum clearly changed in the way of the 3rd period. The change of mitochondria in the accessory sympathetic ganglion cells was of the Ist period, that of mitochondria in other ganglion cells belonging to the change of the 2nd. (4) In the case of strychnine poisoning: Mitochondria in the ganglion cells of the anterior and posterior horn of the spinal cord showed the change of the 3rd period. (5) In the case of chronic nicotinism: The changes of the motor nerve cells in the anterior horn of the spinal cord and in the spinal ganglion cells were remarkable and were between the 2nd and 3rd period. (D) In the case of B-avitaminosis (rice-disease): The changes of mitochondria in the ganglion cells of the cerebellum and in the accessory sympathetic ganglion cells were strongest. And in various ganglion cells, mitochondria showed Ute change of the Ist period. As a result of these experiments, I recognized the clear distinction between the morbid changes of mitochondria in various ganglion cells and their changes after death. Furthermore I found during these experiments that the changes of Nissl bodies in various ganglion cells are the Same as those of mitochondria, light coloring, dark coloring, abnormal coloring, swelling, reducing, changing into granules, connecting with each other, grouping in net forms, fusing into drops or disappearing. As mitochondria and Nissl bodies in various ganglion cells changed, other substances also underwent changes: the nerve cell bodies swelled or reduced, the protoplasm besame abnormally colored, nerve cell processes became smaller or invisible, some big or little vacuoles appeared in those cells, and the nuclei underwent changes.

各種神經節細胞みとこんどりあノ形態學的研究 : 第3編各種神經節細胞みとこんどりあノ病的變化ニ關スル研究

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