半夏瀉心湯と塩酸イリノテカン併用時の便秘発現と塩酸イリノテカンの投与量  [in Japanese] Retrospective Investigation of Constipation Occurrence in Case of Combined Use of Irinotecan Hydrochloride (CPT-11) and Hange-shashin-to and Relationship with CPT-11 Dose  [in Japanese]

The administration of Hange-shashin-to is effective in preventing diarrhea caused by irinotecan hydrochloride (CPT-11) when they are coadministered but a high incidence of constipation has been reported when CPT-11 is used in combination with anti-diarrhea drugs. As many aspects of the occurrence of constipation with the combined use of Hange-shashin-to and CPT-11 were unclear, we decided to clarify the occurrence of constipation and its relationship with the CPT-11 dosage. To do this, we retrospectively compared two treatment groups in which Hange-shashin-to had been coadministered with CPT-11 at 60mg/m^2 and 48mg/m^2, respectively. The incidence of constipation was significantly higher in the group treated with CPT-11 at 60mg/m^2 and Hange-shashin-to than that treated with CPT-11 at 48mg/m^2. These results indicate that the occurrence of constipation in such combined use is correlated not only with the CPT-11 dose but also Hange-shashin-to activity. The results also suggest that interaction between Hange-shashin-to and CPT-11 is strongly associated with the occurrence of constipation.