肺気腫手術における`133´Xe SPECTを用いた肺局所異常残気検出の有用性

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  • The impact of dynamic imaging of xenon-133 wash-out in lung reduction surgery for non-bullous emphysema.

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The authors examined the usefulness of 133Xe dynamic single-photon emission computed tomography (SPECT) in identifying areas to be resected by reduction surgery in patients with non-bullous emphysema. METHODS : Eighteen patients with advanced symptomatic emphysema with and without obvious bullae (bullous type, n=10 and non-bullous type, n=8) were examined using 133Xe SPECT. After a 6-min inhalation of 133Xe gas, equilibrium and subsequent wash-out SPECT images were acquired every 30 sec for 6-7 min during spontaneous breathing. The patients were treated with unilateral thoracoscopic resection directed to he abnormal 133Xe retention portions as well as to obvious bullae. RESULTS : All patients demonstrated marked, heterogeneous 133Xe retention on the wash-out images. In the patients with obvious bullae, dynamic SPECT showed abnormal 133Xe retention corresponding to bullae. The patients in the non-bullous type group, who did not have abnormal radiolucencies on chest X-ray CT, also showed abnormal retention with dynamic SPECT. Significant postoperative improvement in objective measures of pulmonary function was observed in both groups. CONCLUSIONS : 133Xe SPECT is useful in identifying regional ventilatory abnormalities in non-bullous emphysema. Unilateral thoracoscopic volume reduction directed to the abnormal 133Xe retention portions is an effec tivetreatment for non-bullous emphysema.

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