Two New Sesquiterpenoids from Solanum lyratum with Cytotoxic Activities

    • REN Yan
    • School of Pharmaceutical Science, Yantai University
    • SHEN Li
    • Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drug and Food
    • ZHANG De-Wu
    • School of Pharmaceutical Science, Yantai University

Abstract

Two new sesquiterpenoids, lyratol C (1) and lyratol D (2), together with two known sesquiterpenoids, dehydrovomifoliol (3) and blumenol A (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by spectroscopic analyses. In vitro, the four compounds showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC_<50> values in the range 3.7-8.1μM.

Journal

Chemical & pharmaceutical bulletin   [List of Volumes]

Chemical & pharmaceutical bulletin 57(4), 408-410, 2009-04-01  [Table of Contents]

The Pharmaceutical Society of Japan

References:  11

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Codes

  • NII Article ID (NAID) :
    110007160654
  • NII NACSIS-CAT ID (NCID) :
    AA00602100
  • Text Lang :
    ENG
  • Article Type :
    NOT
  • ISSN :
    00092363
  • NDL Article ID :
    10194681
  • NDL Source Classification :
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-D167
  • DOI :
    10.1248/cpb.57.408
  • Databases :
    CJP  NDL  NII-ELS  J-STAGE