Disruption of Thyroid Hormone Function by Environmental Pollutants

• Kashiwagi Keiko

  Institute for Amphibian Biology, Graduate School of Science, Hiroshima University

• Furuno Nobuaki

  Institute for Amphibian Biology, Graduate School of Science, Hiroshima University

• Kitamura Shigeyuki

  Nihon Pharmaceutical University

• Ohta Shigeru

  Graduate School of Biomedical Sciences, Hiroshima University

• Sugihara Kazumi

  Graduate School of Biomedical Sciences, Hiroshima University

• Utsumi Kozo

  Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Hanada Hideki

  Institute for Amphibian Biology, Graduate School of Science, Hiroshima University

• Taniguchi Kikuyo

  School of Medical Technology, Sanyo Women's College

• Suzuki Ken-ichi

  Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University

• Kashiwagi Akihiko

  School of Medical Technology, Sanyo Women's College

抄録

A great number of synthetic chemicals are released into the environment, many of which are known or thought to interfere with normal thyroid hormone (TH) function. THs play important roles in regulating growth and development and maintaining metabolic homeostasis. For example, amphibian tadpole metamorphosis is a TH-triggered and controlled developmental process, and has proven to be useful as a screening tool for environmental pollutants suspected of disrupting TH functions. TH disruption is thought to be caused through a variety of mechanisms, including increased thyroxine (T₄) metabolism by uridine diphosphate glucuronyl transferases (UDPGTs), blocking TH signaling through TH receptors (TRs), and induction of mitochondrial membrane permeability transition (MPT). As our knowledge concerning the specific effects of these chemicals is very limited, further research is needed to obtain accurate information to be used in establishing guidelines for the protection of health in humans and wildlife.

収録刊行物

• ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ

  ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ 55 (2), 147-160, 2009

  公益社団法人 日本薬学会

キーワード

• amphibian metamorphosis
• bisphenol A related compound
• brominated flame retardant
• environmental pollutant
• polychlorinated biphenyl
• thyroid hormone disruption

詳細情報

• CRID: 1390282679474444160
• NII論文ID: 110007161008
• NII書誌ID: AA11316464
• DOI: 10.1248/jhs.55.147
• COI: 1:CAS:528:DC%2BD1MXkt1ykurs%3D
• ISSN: 13475207
• ISSN: 13449702
• NDL書誌ID: 10193925
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10193925
• Web Site: http://www.jstage.jst.go.jp/article/jhs/55/2/55_2_147/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009251818
• 本文言語コード: en
• データソース種別:
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  • NDL
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