肝胆路系疾患の血清鉄銅に関する臨床ならびに実験的研究

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タイトル別名
  • カンタンロケイ シッカン ノ ケッセイテツ ドウ ニ カンスル リンショウ ナラビニ ジッケンテキ ケンキュウ
  • CLINICAL AND EXPERIMENTAL STUDIES ON SERUM IRON AND SERUM COPPER IN HEPATOBILIARY DISEASES
  • 原著
  • Original Article

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Serum iron and serum copper were determined togeter with other clinical test on 271 patients with hepatic and biliary diseases, the diagnosis of which was established mainly by liver biopsy, autopsy, and operationfinding. In acute hepatitis the serum iron increased from the onset of jaundice, reaching a peak in 4th week. And in 94.8% of the cases, which were determined during the first four weeks, serum iron was markedly elevated, but in patients with such complication as irondeficient anamia, infection and malignancy it did not necessarily show significant elevation. The peak of serum iron level in acute hepatis was found to delay to that of transaminase, and after serum bilirubin reached to normal level, serum iron returned to normal in 8 th week of jaundice with transaminase activity and B.S.P. though not simultaneously. In cholangiolitic hepatitis the serum iron level elevated and serum copper also increased continuously. In chronic hepatitis and livercirrosis there were many factors which influenced on iron metabolism, and the elevation of serum iron was suspected for the active form. But low or normal serum iron level did not necessarily mean the stable state. The cases of biliary obstruction mainly characterized by inframation and carcinoma. In most cases serum copper elevated and serum iron tended to decrease but the cases in which the serum iron tended to elevate were rare and most of which terminated fatally. In Wilson disease the copper metabolism differed from Inose type hepatocellebral degeneration, there were decreased serum copper and ceruloplasmin activity. Determination of both serum iron and copper were of great value in differential diagnosis of hepatobilliary diseases especially the cases with jaundice, if we took account of the complication which influenced iron and copper metabolism as anamia, infection and malignancy.

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