INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION
この論文をさがす
抄録
Interleukin (IL)-8, a proinflammatory chemokine, has been reported to have angiogenic activity and to be responsible for tumor-associated angiogenesis in several cancers. The polymorphism IL-8 T-251A (rs4073) is known to be associated with the expression of IL-8 protein and is related to several cancers. A serum anti-p53 antibody, a new tumor marker, increases in accordance with the mutation of tumor suppressor gene p53. Previous studies have reported the association between IL-8 and p53 mutation in cancer cells or tissues. Therefore, we hypothesized that IL-8 polymorphism might be associated with serum anti-p53 antibody levels. Study subjects were 197 participants (103 males and 94 females, aged 15 to 56 years) who were enrolled in a case-control study on peptic ulcer disease from January to March 2007 in the Uzbekistan Republic. Serum anti-p53 antibody, CEA, and CA19-9 levels were measured, and IL-8 T-251A was genotyped. The A allele frequency in control subjects was 0.48, which is close to the previous reports for Caucasian populations. The proportion of subjects with positive anti-p53 antibodies (higher than 1.3 U/mL) was greater for AA genotype carriers compared to T allele carriers (17% for AA, and 6% for TA+TT; OR 3.4, p = 0.025 after adjusting for age, sex, comorbidity and ethnicity). Such a difference was not observed for either CEA or CA19-9. We demonstrated that the IL-8 -251 AA genotype was associated with higher anti-p53 antibodies than those of the reference range. Further studies are warranted to clarify whether those with this genotype carrier are susceptible to malignant diseases.
収録刊行物
-
- Nagoya Journal of Medical Science
-
Nagoya Journal of Medical Science 71 (3-4), 151-156, 2009-09
Nagoya University School of Medicine
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390009224622923904
-
- NII論文ID
- 110007355833
-
- NII書誌ID
- AA00750877
-
- ISSN
- 21863326
- 00277622
-
- HANDLE
- 2237/12351
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用可