Genotoxicity studies of ubidecarenone (coenzyme Q10) manufactured by bacteria fermentation
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- Yamaguchi Noriko
- Bozo Research Center Inc.
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- Nakamura Kaori
- Bozo Research Center Inc.
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- Oguma Yoshihiro
- Bozo Research Center Inc.
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- Fujiwara Sho
- Bozo Research Center Inc.
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- Takabe Michihito
- Bozo Research Center Inc.
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- Sono Akira
- Bozo Research Center Inc.
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- Kawasaki Tsuneshirou
- Asahi Kasei Pharma Corporation
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- Otsubo Kazumasa
- Asahi Kasei Pharma Corporation
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- Wakigawa Koichi
- Asahi Kasei Pharma Corporation
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抄録
Ubidecarenone (coenzyme Q10) has been widely used as a complementary therapy in heart failure and as a dietary supplement for over two decades. Ubidecarenone is manufactured by organic synthesis, yeast (non-Saccharomyces cerevisiae) fermentation, or bacteria fermentation. There are many reports on the safety of ubidecarenone. However, genotoxicity of ubidecarenone manufactured by bacteria fermentation has not been reported. We carried out genotoxicity evaluation of ubidecarenone manufactured by bacteria fermentation through the bacterial reverse mutation test (Ames test) and in vitro chromosome aberration test in compliance with the Japanese guidelines on genotoxicity testing of pharmaceuticals and the Organization for Economic Co-operation and Development (OECD) guidelines for testing chemicals. The results indicate neither increase of revertant colonies nor chromosome aberration, suggesting that the ubidecarenone manufactured by bacteria fermentation has no genotoxic activities under the condition of this study.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 34 (4), 389-397, 2009
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390001204903248640
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- NII論文ID
- 110007359661
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 10405205
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可