P-53 Proteome analysis of rat serum proteins accumulated onto octacalcium phosphate (OCP) crystals

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P-53 リン酸オクタカルシウム(OCP)に集積するラット血清由来タンパク質のプロテオーム解析(生体組織・毒性,一般講演(ポスター発表),第54回日本歯科理工学会学術講演会) [in Japanese] P-53 Proteome analysis of rat serum proteins accumulated onto octacalcium phosphate (OCP) crystals [in Japanese]

- 金子裕史 Kaneko H
- 東北大院・歯・歯内歯周:東北大院・歯・機能創建 Tohoku univ.
- 上家潤一 Kamiie J
- 麻布大・獣医・病理 Azabu univ.
- 穴田貴久 Anada T
- 東北大院・歯・機能創建 Tohoku univ.
- 本田義知 Honda Y
- 東北大院・歯・機能創建 Tohoku univ.
- 鎌倉慎治 Kamakura S
- 東北大院・医工・骨再生 Tohoku univ.
- 寺崎哲也 Terasaki T
- 東北大院・薬・薬物送達 Tohoku univ.
- 島内英俊 Shimauchi H
- 東北大院・歯・歯内歯周 Tohoku univ.
- 鈴木治 Suzuki O
- 東北大院・歯・機能創建 Tohoku univ.

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Abstract

Previous study showed that octacalcium Phosphate (OCP) enhances bone formation and accumulation of circulating serum proteins on its surface if implanted in bone defect. In this study, serum proteins accumulated on OCP and hydroxyapatite (HA) in vitro were analyzed by proteomic approaches using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 139 proteins were detected from OCP surface in total. 46 of them were indentical to the proteins accumulated on HA. The difference in the proteins found could be a potential factor to display the distinct osteoconductive nature between OCP and HA.

Journal

Journal of the Japanese Society for Dental Materials and Devices [List of Volumes]

Journal of the Japanese Society for Dental Materials and Devices 28(5), 276, 2009-09-10 [Table of Contents]

The Japanese Society for Dental Materials and Devices (JSDMD)

References: 5

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