視神経脊髄炎(NMO)における免疫吸着療法の検討(神経内科学教室岩田誠教授退任記念特別号) Immunoadsorption Plasma Pheresis Therapy for Neuromyelitis Optica(Special Issue in Hornor of the Retirement of Professor Makoto Iwata at the Department of Neurology, Tokyo Women's Medical University)

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著者

    • 大橋 高志 OHASHI Takashi
    • 東京女子医科大学医学部神経内科学 Department of Neurology, Tokyo Women's Medical University, School of Medicine
    • 太田 宏平 OTA Kohei
    • 東京女子医科大学医学部神経内科学:東京理科大学理学部 Department of Neurology, Tokyo Women's Medical University, School of Medicine:Faculty of Science, Tokyo University of Science
    • 大原 久仁子 OHARA Kuniko
    • 東京女子医科大学医学部神経内科学 Department of Neurology, Tokyo Women's Medical University, School of Medicine
    • 竹内 千仙 TAKEUCHI Chisen
    • 東京女子医科大学医学部神経内科学 Department of Neurology, Tokyo Women's Medical University, School of Medicine
    • 岩田 誠 IWATA Makoto
    • 東京女子医科大学医学部神経内科学 Department of Neurology, Tokyo Women's Medical University, School of Medicine

抄録

Neuromyelitis optica (NMO) is an idiopathic inflammatory demyelinating disease of the central nervous system characterized by optic neuritis and myelitis. Recently, anti aquaporin-4 antibody, specifically detected in sera from NMO patients, was discovered. The effectiveness of immunoadsorption plasma pheresis (IAPP) therapy for treating acute exacerbations of NMO has not been well evaluated; thus, accumulation of therapeutic experience for this disease is important. We report 3 patients with acute exacerbations of NMO. These patients were unresponsive to intravenous methylprednisolone therapy but showed significant improvement after IAPP therapy. IAPP therapy was well tolerated and effective for a patient with acute exacerbation during pregnancy. We conclude that IAPP therapy is a therapeutic option for patients with a fulminant attack of NMO. It is relatively safe and applicable for patients with acute exacerbation during pregnancy.

Neuromyelitis optica (NMO) is an idiopathic inflammatory demyelinating disease of the central nervous system characterized by optic neuritis and myelitis. Recently, anti aquaporin-4 antibody, specifically detected in sera from NMO patients, was discovered. The effectiveness of immunoadsorption plasma pheresis (IAPP) therapy for treating acute exacerbations of NMO has not been well evaluated; thus, accumulation of therapeutic experience for this disease is important. We report 3 patients with acute exacerbations of NMO. These patients were unresponsive to intravenous methylprednisolone therapy but showed significant improvement after IAPP therapy. IAPP therapy was well tolerated and effective for a patient with acute exacerbation during pregnancy. We conclude that IAPP therapy is a therapeutic option for patients with a fulminant attack of NMO. It is relatively safe and applicable for patients with acute exacerbation during pregnancy.

収録刊行物

  • 東京女子医科大学雑誌

    東京女子医科大学雑誌 78(臨時増刊号), E94-E98, 2008-02-25

    東京女子医科大学

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    110007524787
  • NII書誌ID(NCID)
    AN00161368
  • 本文言語コード
    JPN
  • 資料種別
    Journal Article
  • 雑誌種別
    大学紀要
  • ISSN
    00409022
  • NDL 記事登録ID
    9463690
  • NDL 雑誌分類
    ZS7(科学技術--医学)
  • NDL 請求記号
    Z19-400
  • データ提供元
    CJP引用  NDL  NII-ELS  IR 
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