2型糖尿病患者における大血管障害合併と動脈硬化関連遺伝子多型の検討

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タイトル別名
  • 2ガタ トウニョウビョウ カンジャ ニ オケル ダイ ケッカン ショウガイ ガッペイ ト ドウミャク コウカ カンレン イデンシ タケイ ノ ケントウ
  • Diabetic Macro angiopathy and Genetic Polymorphisms in Japanese Patients with Type 2 Diabetes

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The main cause of mortality in type 2 diabetic patients is macroangiopathy including coronary heart disease (CHD), cerebrovascular disease (CVD), and obstractive atherosclerosis (ASO). Recent genetic studies showed that these vascular diseases in non-diabetic patients were largely associated with certain genetic polymorphisms. We therefore investigated the relationship between macroangiopathy and the genetic polymorphisms in Japanese patients with type 2 diabetes by a case-control study. A total of 157 patients with type 2 diabetes were divided into 81 with either CHD, CVD or ASO (positive group) and 76 without all (negative group). Two groups were matched with age, duration, HbAlc and lipid metabolism. Healthy individuals who had no abnormality of glucose and lipid metabolisms served as controls. The gene polymorphisms used in this study were as follows; the deletion/insertion allele of angiotensin-converting enzyme (ACE) gene, 1166A/C allele of angiotensin II type I receptor (AT_1R) gene, PI^<A1>/PI^<A2> allele of platelet glycoprotein IIIa receptor (GPIIIa) gene, TaqIB and Intl4G/A allele of cholesteryl ester transfer protein (CETP), 188Gly/Glu allele of lipoprotein lipase (LPL) gene, 4a/b allele of endothelial nitric oxide synthase (eNOS) gene, 192Gln/Arg allele of paraoxonase (PON) gene, and 677C/T allele of methylenetetrahydrofolate reductase (MTHFR) gene. These gene polymorphisms in healthy control were on the way to Hardy-Weinberg equilibium. The result showed that there was no statistical difference in the polymorphisms between the positive and negative groups. It suggests that the development of macroangiopathy in type 2 diabetes was not associated these gene polymorphisms.

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