T0502-1-5 2色低コヒーレンス光断層画像を用いた生体組織における薬剤浸潤度のマイクロ断層可視化法(マイクロ・ナノ領域におけるバイオ・熱流体の融合学術創成(1)バイオMEMS)

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  • T0502-1-5 Study on in vivo micro-visualizing technique of delivered drug infiltration using 2-Color Optical Coherence Dosigraphy

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Recently, clinical diagnoses applying drug delivery system (DDS), e.g. photodynamic diagnosis, have been being developed. Nevertheless, it is quite difficult to in vivo diagnose spatiotemporal distribution of drug infiltration. Previously, we proposed a tomographic visualizing assay of DDS, namely 2-Color Optical Coherence Dosigraphy (2C-OCD), which was based on optical coherence tomography using 2-Color light sources having different optical absorbance of DDS drug. In this study, the bio-availability of 2C-OCD was investigated by applying 2C-OCD to atherosclerotic rabbit aorta with macrophage marker AlPcS administered. Consequently, AlPcS accumulation, visualized by 2C-OCD, was only observed at plaque lesion significantly, and then apppered to be similar to macrophage invasion obtained by RAM11 immuno-staining. Therefore, it was confirmed that 2C-OCD could detect the drug infiltration in biomedical tissue as well as the vulnerability of atherosclerotic plaque attributed to macrophage invasion.

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