敗血症性多臓器不全に対するエンドトキシン吸着療法(PMX-DHP)(<特集>アフェレシスの新しい適応をめぐって)

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  • Effects of Direct Hemoperfusion with Polymyxin B Immobilized Fiber (PMX-DHP) for Patients with Septic Multiple Organ Failure

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For patients with septic shock/septic multiple organ failure, Early Goal-Direct Therapy using direct hemoperfusion with polymyxin B immobilized fiber (PMX-DHP) brings about a significant improvement in circulation, respiratory condition and multiple organ survival evaluated by the SOFA score. It is suggested that its mechanism involves modulating mediators, such as endogenous cannabinoids, cytokines and HMGB-1, and controlling the biological response. In recent years, many reports from foreign countries concerning PMX-DHP have been published. PMX-DHP is a useful and effective treatment method, so the evaluation of PMX-DHP must be performed inside and outside the country. In the future, it is expected that PMX-DHP treatment will be incorporated in the treatment strategy of septic shock and septic multiple organ failure around the world.

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