ストレスがラット腸管免疫に及ぼす影響 ―アレルギー遺伝子素因・ Brown Norwayラットにおける検討―

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  • ストレス ガ ラット チョウカン メンエキ ニ オヨボス エイキョウ アレルギー イデンシ ソイン Brown Norway ラット ニ オケル ケントウ

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To study the effects of physical stress（electric foot shock; FS）on intestinal immune function，the immunoglobulin productions by the lymphocytes in stressed Brown Norway（BN）rats were observed. Physical stress was induced using the communication box. Stresses were exposed for 2 hours a day，and the treatments were maintained for 14 consecutive days. Lymphocytes were isolated from mesenteric lymph node （MLN） and spleen using lympholyte-rat. No significant differences were found in plasma IgA，IgG or IgE concentration of the FS group. Production of IgG in the FS group was significantly lower than the control group in the MLN lymphocytes. Likewise，the level of IgA in the FS group was slightly lower than the control group in the MLN lymphocytes. As for IgE production in the MLN lymphocytes，these were significantly high in the FS group compared to that in the control group. No significant differences were found in the spleen lymphocytes. These results demonstrated that the intestinal immune functions of BN rats with genetic causes of allergosis were decreased with physical stress.

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