DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING IN PATIENTS WITH POSSIBLE IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS BEFORE AND AFTER TAP TEST

• 出村 光一朗

  Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences

• 間瀬 光人

  Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences

• 大沢 知士

  Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences

• 服部 学

  Department of Neurology, Nagoya City University Graduate School of Medical Sciences

• 笠井 治昌

  Department of Central Radiology, Nagoya City University Hospital

• 宮地 利明

  Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

• 山田 和雄

  Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences

抄録

Dilated ventricles in patients with idiopathic normal pressure hydrocephalus (INPH) may cause dysfunction of Periventricular white matter. However, the pathophysiological mechanism of INPH symptoms is not well understood. In this study, we investigated axonal water dynamics using diffusion tensor imaging (DTI) in 36 patients with possible INPH before and after cerebrospinal fluid (CSF) tap test. Nineteen cases were negative for tap test (negative group) and 17 cases were positive (positive group). Regional apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured with 1.5T magnetic resonance imaging system. ADC values were significantly decreased in the frontal periventricular region and the body of the corpus callosum of the positive group after tap test (P<0.05). FA values were significantly increased in the body of the corpus callosum of both group after tap test (P<0.05). These results suggest that water molecules at the extracellular space might be moved to intraventricular space by reduction of the CSF in the lateral ventricles after tap test, resulting in decreased ADC values in the periventricular regions. After tap test, compression against axonal fibers in the body of the corpus callosum might be relieved by reduction of the CSF in the lateral ventricles, resulting in increased FA values.

収録刊行物

• Nagoya medical journal

  Nagoya medical journal 50 (4), 177-186, 2010-02-01

  名古屋市立大学

キーワード

• idiopathic normal pressure hydrocephalus
• diffusion tensor imaging
• fractional anisotropy
• apparent diffusion coefficient
• tap test

詳細情報

• CRID: 1571980076972378240
• NII論文ID: 110008138503
• NII書誌ID: AA00750902
• ISSN: 00277649
• 本文言語コード: en
• データソース種別:
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