Isolation of (S)-N-feruloyl Normetanephrine from Achyranthes fauriei and Determination of Its Absolute Configuration :

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N-Feruloyl normetanephrine ((-)-1) was isolated from the root of Achyranthes fauriei. The amide (S)-1 was synthesized based on asymmetric dihydroxylation of styrene derivatives. Thus the absolute configuration of natural (-)-1 was identified as S by a comparison between the optical rotation of the natural product and that of synthetic (S)-1.

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