T0201-3-2 衝撃圧力が培養血管内皮細胞のVE-カドヘリンに与える影響([T0201-3]細胞の構造と流れにおけるマイクロ・ナノスケール解析(3))

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  • T0201-3-2 The effects of impact pressure on VE-cadherin in cultured endothelial cells

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Human umbilical veinendothelial cells (HUVECs) were exposed to an impact pressure of -100 kPa and changes in morphology of HUVECs and expression of vascular entodhelial (VE)-cadherin were examined in order to investigate effect of exposure to impact pressure on endothelial permeability. In the results, HUVECs exposed to impact pressure were absent locally. VE-cadherin in control were continuously expressed along peripheral region of cells. However, VE-cadherin in HUVECs exposed to impact pressure were sparsely expressed along peripheral region of cells and partly distributed in cells. These findings suggest that the exposure to impact pressure may change the expression and the distribution of VE-cadherin, influencing endothelial permeability.

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