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The antihypertensive effect of magnesium lithospermate B isolated from Salviae Miltiorrhizae Radix was evaluated using spontaneously hypertensive rats (SHR). Oral administration of magnesium lithospermate B lowered the systolic, mean and diastolic blood pressures in SHR, in comparison with the progressive hypertension observed in untreated control animals. Urinary excretion of both kallikrein and sodium was increased significantly in rats given magnesium lithospermate B. These data suggest that magnesium lithospermate B is useful for treatment of essential hypertension.