Antiperoxidation Activity of Traditional Chinese Prescriptions and Their Main Crude Drugs In Vitro
The antiperoxidation activities of 80 traditional Chinese prescriptions and 30 of their constituent crude drugs were studied in detail using a lipid peroxidation generation system mediated by addition of H_2O_2/Fe^<2+> to rat liver homogenate. It was found that the prescriptions with the greatest protective activity against peroxidation were, in order to effectiveness, Daio-botampi-to, Dai-saiko-to, Mashi-nin-gan, Otsuji-to, Saiko-keishi-kankyo-to, Shakuyaku-kanzo-to and Shishi-hakuhi-to, of which the first 5 showed relatively lower IC_<50> values. In an addition, among the crude drugs tested, Glycyrrhizae Radix, Rhei Rhizoma, Scutellariae Radix, Cinnamomi Cortex and Ephedrae Herba showed the strongest inhibition of lipid peroxidation formation. Almost all the prescriptions which had antioxidant effects were composed of one or more of these crude drugs.