感応丸処方製剤の薬理学的研究 Pharmacological Studies of One of "Kanno-gan" Formulations
"Kyushin Kanno-gan Ki," one of "Kanno-gan" formulations, was studied for its effects on peripheral blood flow, cutaneous and rectal temperatures, obesity, hyperlipidemia, autonomic imbalance and hanging stress-induced decreases in rectal temperature and in sexual and learning behaviour. This medicine increased the blood flow in the auricle, foot pad, gastric mucosa and ileum, and the temperature in the auricle, foot pad and rectum in normal rats. It also decreased the Lee index and the retroperitoneal white adipose tissue weight in mono sodium glutamate-induced obese rats and the total cholesterol, triglyceride and atherogenic index in high cholesterol diet-fed rats. This medicine facilitated thermogenesis in the brown adipose tissue (BAT) induced by administration of norepinephrine or nutriment in rats. Therefore, the anti-obesity and -hyperlipidemic effects may result from the facilitation of BAT thermogenesis and rise in body temperature due to increase in peripheral blood flow. Furthermore, this medicine counteracted the SART stress-induced autonomic imbalance in mice by inhibiting decreases in nociceptive threshold and ACh response in isolated duodenum. It may have also a nutritive and tonic effect, because it protected mice against the stress-induced decrease of rectal temperature and sexual and learning behaviour. These effects of this medicine may mainly originate from one of its ingredients, musk known to have the mentioned effects.