海藻の生物活性に関する研究(III) : 発がんプロモーター抑制活性及びアルドース・レダクターゼ阻害活性 Studies on the Biological Activities of Marine Algae (III) : Antitumor Promoting Activity and Inhibitory Effect on Aldose Reductase

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抄録

Ethyl acetate, methanol and aqueous extracts from 11 species of marine algae collected in Japan were assayed for their in vitro anti-tumor promoting activity and for their inhibitory effect on human aldose reductase. The anti-tumor promoting activity was examined by using the inhibition tests of ^<32>Pi incorporation into phospholipids of HeLa cells and Epstein Barr virus (EBV) activation in Raji cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Of the extracts tested, AcOEt extracts from Sargassum patens C. Agardh and Sargassum muticum C. Agardh (Phaeophyta) showed high inhibitory activities on ^<32>Pi incorporation method and an AcOEt extract of Sargassum muticum, a MeOH extract of Ecklonia cave Kjellman (Phaeophyta) and aqueous extracts from Amphiroa zonata Yendo and Gigartina tenella Harvey (Rhodophyta) on EBV activation method. The inhibitory effects on human aldose reductase of marine algae were found in an AcOEt extract from Ecklonia cave, from which was isolated l-(3',5'-dihydroxyphenoxy)-2,4,7,9-tetra- hydroxydibenzo-1,4-dioxin (1).

収録刊行物

生薬學雜誌   [巻号一覧]

生薬學雜誌 51(2), 162-169, 1997-04-20  [この号の目次]

日本生薬学会

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各種コード

  • NII論文ID(NAID) :
    110008731747
  • NII書誌ID(NCID) :
    AN10438628
  • 本文言語コード :
    JPN
  • 資料種別 :
    NOT
  • ISSN :
    13403443
  • NDL 記事登録ID :
    4229266
  • NDL 雑誌分類 :
    ZS51(科学技術--薬学)
  • NDL 請求記号 :
    Z19-375
  • 収録DB :
    CJP書誌  NDL  NII-ELS