統計学的手法を用いた生薬選定法の検討 : 抗炎症作用を有する大黄の探索 [in Japanese] Studies on selection method of crude drugs by statistical analysis. : Research on Rhubarb having anti-inflamatory activity. [in Japanese]
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Contents of 19 components in 34 Rhubarb samples were determind by HPLC analysis, and their 5-LOX inhibitory activities were tested. It was revealed that 5-LOX inhibition activities can be estimated by the contents of 8 components (physcion, emodin-1-O-β-D-glucoside, sennoside A, catechin, (-)-epicatechin 3-O-gallate, procyanidin B-2 3,3'-di-O-gallate, lindleyin and 3,5,4'-trihydroxystilbene-4'-(6"-O-galloyl)-glucose) in Rhubarb using a muliple regression analysis. The results obtained here were further supported by phorbol ester induced ear swelling tests in mice.