Antiproliferative Activity of Some Catechins against Her2/neu-Overexpressing Human Breast Carcinoma SKBR3

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Abstract

Four catechins were assessed for antiproliferative activities against human breast carcinoma cells SKBR3 overexpressing Her2/neu as well as against human colon carcinoma cells SW620, not overexpressing Her2/neu, which serves as a reference. As a result, (-)-epigallocatechin gallate and (-)-epigallocatechin inhibited the growth of SKBR3 cells at nearly the same concentration (IC_<50> 37.7±5.7nM and 41.7±9.2 μM, respectively). In contrast, the catechol-type catechins: (-)-epicatechin and (+)-catechin showed much lower activities (both IC_<50> >150 μM). Furthermore, no catechins inhibited SW620 cell growth even with 150 μM. These results suggested that not only (-)-epigallocatechin gallate but also (-)-epigallocatechin can be a potential candidate for prognostic treatments of breast cancer overexpressing Her2/neu protein.

Journal

Natural medicines   [List of Volumes]

Natural medicines 57(1), 31-33, 2003-02-20  [Table of Contents]

The Japanese Society of Pharmacognosy

References:  6

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Codes

  • NII Article ID (NAID) :
    110008732232
  • NII NACSIS-CAT ID (NCID) :
    AN10438628
  • Text Lang :
    ENG
  • Article Type :
    SHO
  • ISSN :
    13403443
  • NDL Article ID :
    6489506
  • NDL Source Classification :
    ZS51(科学技術--薬学)
  • NDL Call No. :
    Z19-375
  • Databases :
    CJP  NDL  NII-ELS