Antiproliferative Activity of Some Catechins against Her2/neu-Overexpressing Human Breast Carcinoma SKBR3

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Four catechins were assessed for antiproliferative activities against human breast carcinoma cells SKBR3 overexpressing Her2/neu as well as against human colon carcinoma cells SW620, not overexpressing Her2/neu, which serves as a reference. As a result, (-)-epigallocatechin gallate and (-)-epigallocatechin inhibited the growth of SKBR3 cells at nearly the same concentration (IC_<50> 37.7±5.7nM and 41.7±9.2 μM, respectively). In contrast, the catechol-type catechins: (-)-epicatechin and (+)-catechin showed much lower activities (both IC_<50> >150 μM). Furthermore, no catechins inhibited SW620 cell growth even with 150 μM. These results suggested that not only (-)-epigallocatechin gallate but also (-)-epigallocatechin can be a potential candidate for prognostic treatments of breast cancer overexpressing Her2/neu protein.

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各種コード

  • NII論文ID(NAID)
    110008732232
  • NII書誌ID(NCID)
    AN10438628
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13403443
  • NDL 記事登録ID
    6489506
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-375
  • データ提供元
    CJP書誌  NDL  NII-ELS 
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