Stress in Children with Pervasive Developmental Disorders

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type:Original

The purpose of this study is to examine urinary 17-hydroxycorticosteroid (OHCS) excretion as a measureof stress response in controls and in children with pervasive developmental disorders (PDDs) accompaniedby mental retardation( MR, intelligence quotient[ IQ]<70)( low-functioning PDD:LFPDD) or notaccompanied by MR( IQ≧70)( high-functioning PDD:HFPDD). Prospective, non-randomized study of 24children with LFPDD ─ 17 with autism and seven with PDDs not otherwise specified( PDDs-NOS) ─ and14 children with HFPDD ─ 11 with PDDs-NOS and three with Asperger's disorders. Urinary 17-OHCSwas measured between June 2002 and June 2004. In 21 of 24 LFPDD subjects and 8 of 14 HFPDD subjectsa second measurement was taken 6 to 12-months after the first, after the subjects had received interventionfor developmental disorders. Baseline urinary 17-OHCS levels in both LFPDD( p<0.0005) and HFPDD(p<0.005) were significantly higher than in controls. LFPDD subjects had significantly greater (p<0.05)levels of this stress hormone than did HFPDD subjects. Levels of 17-OHCS in both LFPDD (p<0.05) andHFPDD (p<0.05) decreased significantly after 6 to 12 months of intervention. PDD subjects showed higherlevels of 17-OHCS than controls and showed a significant reduction in the level of stress indicator after theyhad received intervention for developmental disorders.

identifier:2

identifier:KJ00007523020

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