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- MISAWA Masaki
- AIST
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- HAYASHI Kazuhiko
- AIST
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- SHIRASAKI Yoshio
- AIST
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- TAKAHASHI Junko
- AIST
Bibliographic Information
- Other Title
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- 1104 マイクロX線CTによる再生骨軟骨の構造評価(OS13-(5)オーガナイズドセッション《生体医工学及びバイオマテリアル》)
Abstract
Bone-cartilage bi-phase element was constructed of native chondrocyte of beagle and P-TCP scaffold block. Assembling such a regenerative element enables to form arbitral configuration which fits the shape of large defect on joints without sacrificing other part of the body. The bone-cartilage bi-phase element was grafted in a distal femur condyle of a beagle for 2 month. The extracted femur sample including the bi-phase element was scanned by a high-resolution, micro-focus X-ray tomography to investigate the fusion process in vivo. The 3D tomography measurement showed that the hosting cancellous bone intruded into the scaffold and a part of the scaffold was replaced with the cancellous bone. Mechanical properties of grafted element was evaluated by a push-out test, indicating that scaffold was firmly fused with the cancellous bone of the host. Also, a preliminary microarray gene expression analysis was conducted to investigate the effect of X-ray radiation on the regenerative devices.
Journal
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- The Proceedings of Ibaraki District Conference
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The Proceedings of Ibaraki District Conference 2010.18 (0), 307-308, 2010
The Japan Society of Mechanical Engineers
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Details 詳細情報について
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- CRID
- 1390282680831148800
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- NII Article ID
- 110008745928
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- ISSN
- 24242683
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed