近縁種ゲノム配列を用いたヒトゲノム配列未決定領域の塩基配列決定  [in Japanese] Sequencing of undetermined regions in the human genome with the aid of the genomic sequences of closely-related species  [in Japanese]

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Abstract

ヒトゲノムプロジェクトは2004年に完了し、解読されたヒトゲノム配列は広く利用されている。しかしながら現在でもユークロマチン領域に関しても1%程度が配列未決定領域として残されている。一方でヒトゲノム上にマッピングされないヒトcDNA配列が存在しており、機能既知の遺伝子が未だ配列未決定領域内に存在することが示唆される。本研究ではヒトに近縁な霊長類のゲノム配列を利用することで、ヒトゲノム配列未決定領域の塩基配列決定を行った。The human genome project was completed in 2004, and the data of the finished reference human genome has been available to the public since then. However, there still remain undetermined regions (gaps) even in euchromatin, which account for about 1% of the genome. On the other hand, there are cDNA sequences that are not mapped onto the reference human genome, suggesting that some functional genes exist in undetermined regions. In this study, we sequenced one of such undetermined regions and closed a gap by referringthe genomic sequences of human's close relatives.

The human genome project was completed in 2004, and the data of the finished reference human genome has been available to the public since then. However, there still remain undetermined regions (gaps) even in euchromatin, which account for about 1% of the genome. On the other hand, there are cDNA sequences that are not mapped onto the reference human genome, suggesting that some functional genes exist in undetermined regions. In this study, we sequenced one of such undetermined regions and closed a gap by referringthe genomic sequences of human's close relatives.

Journal

  • IPSJ SIG technical reports  

    IPSJ SIG technical reports 2012-BIO-28(6), 1-2, 2012-03-21 

    Information Processing Society of Japan (IPSJ)

Codes

  • NII Article ID (NAID)
    110008803111
  • NII NACSIS-CAT ID (NCID)
    AA12055912
  • Text Lang
    JPN
  • Article Type
    Technical Report
  • ISSN
    09196072
  • Data Source
    IPSJ 
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