Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia
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- Takashima Masaki
- Department of Human Pathology, Tokyo Medical and Dental University
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- Kawachi Hiroshi
- Department of Human Pathology, Tokyo Medical and Dental University
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- Yamaguchi Tsukasa
- Department of Human Pathology, Tokyo Medical and Dental University
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- Nakajima Yutaka
- Department of Human Pathology, Tokyo Medical and Dental University
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- Kitagaki Keisuke
- Department of Human Pathology, Tokyo Medical and Dental University
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- Sekine Masaki
- Department of Human Pathology, Tokyo Medical and Dental University
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- Iida Tadatsune
- Department of Human Pathology, Tokyo Medical and Dental University
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- Takemura Kosuke
- Department of Human Pathology, Tokyo Medical and Dental University
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- Kawano Tatsuyuki
- Department of Esophageal and General Surgery, Tokyo Medical and Dental University
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- Eishi Yoshinobu
- Department of Human Pathology, Tokyo Medical and Dental University
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Histologic evaluation of low-grade or high-grade intraepithelial neoplasia (LG-IN or HG-IN) of the esophagus is important for estimating the risk of progression to invasive carcinoma. Discrimination between LG-IN and HG-IN, or neoplasia and non-neoplastic lesion (NNL), however, is occasionally difficult. This study was designed to evaluate whether cytokeratin expression can be used for discrimination of these lesions. Esophageal Iodine-unstained lesions (n=154), less than 10 mm, were classified into HG-IN, LG-IN, and NNL. These lesions together with 154 foci of normal esophageal epithelium (NEE) were examined by immunohistochemistry for cytokeratins (CK4 and CK13), p53 overexpression, and the MIB-1 labeling index. The ratios of CK4- and CK13-positive staining were scored from 1 to 3. The CK4- and CK13-positive staining ratios were decreased in NNL (73% and 78%), LG-IN (55% and 69%), and HG-IN (33% and 48%), compared to NEE (91% and 95%). The differences between LG-IN and HG-IN, neoplasia and NNL, and among these three lesions and NEE were statistically significant (p < 0.005). The cytokeratin scores correlated with the MIB-1 labeling index (both: p < 0.0001), but not with p53 overexpression. CK4 and CK13 immunohistochemistry could be an objective method for evaluating the risk for progression to invasive carcinoma.
収録刊行物
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- Journal of medical and dental sciences
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Journal of medical and dental sciences 59 (1), 17-28, 2012-03
東京医科歯科大学
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詳細情報 詳細情報について
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- CRID
- 1573105976848249088
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- NII論文ID
- 110008904367
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- NII書誌ID
- AA12028964
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- ISSN
- 21859132
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles