Effect of Eleutherococcus senticosus and Its Components on Sex- and Learning-Behaviours and Tyrosine Hydroxylase Activities of Adrenal Gland and Hypothalamic Regions in Chronic Stressed Mice :

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著者

    • KAMEGAYA TOSHIHIKO
    • Experiment Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, University of Tokyo
    • IWAI AKIHIKO
    • Experiment Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, University of Tokyo
    • SAITO HIROSHI
    • Experiment Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, University of Tokyo
    • SANADA SHUICHI
    • Department of Pharmacognosy, School of Pharmaceutical Sciences, Showa University
    • IDA YOSHITERU
    • Department of Pharmacognosy, School of Pharmaceutical Sciences, Showa University
    • SHOJI JUNZO
    • Department of Pharmacognosy, School of Pharmaceutical Sciences, Showa University

抄録

Eleutherococcus senticosus and its components, syringin and syringaresinol di-O-glucoside, were studied for their effect on sex behaviours and on acquired conditioned reactions in mice exposed to chronic "hanging stress." Rectal temperature was recorded during exposure to the stress, and adrenal gland weight, tyrosine hydroxylase activity in adrenal gland and hypothalamic regions, and corticosterone content in adrenal gland and serum were measured 24 hr after the final exposure to stress. A water extract from Eleutherococcus senticosus and syringin were shown to protect mice from the stress-induced decreases in sex behaviors and in rectal temperature. Syringaresinol di-O-glucoside protected the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the stress-induced enlargement of adrenal gland. They have no effect however on the stress-induced increase in tyrosine hydroxylase activity in adrenal gland and hypothalamic regions, and on corticosterone contents in adrenal gland and serum.

Eleutherococcus senticosus and its components, syringin and syringaresinol di-O-glucoside, were studied for their effect on sex behaviours and on acquired conditioned reactions in mice exposed to chronic "hanging stress." Rectal temperature was recorded during exposure to the stress, and adrenal gland weight, tyrosine hydroxylase activity in adrenal gland and hypothalamic regions, and corticosterone content in adrenal gland and serum were measured 24 hr after the final exposure to stress. A water extract from Eleutherococcus senticosus and syringin were shown to protect mice from the stress-induced decreases in sex behaviors and in rectal temperature. Syringaresinol di-O-glucoside protected the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the stress-induced enlargement of adrenal gland. They have no effect however on the stress-induced increase in tyrosine hydroxylase activity in adrenal gland and hypothalamic regions, and on corticosterone contents in adrenal gland and serum.

収録刊行物

  • 生薬学雑誌

    生薬学雑誌 39(3), 238-242, 1985

    日本生薬学会

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    110008908085
  • NII書誌ID(NCID)
    AN00116895
  • 本文言語コード
    ENG
  • 資料種別
    Journal Article
  • ISSN
    00374377
  • NDL 記事登録ID
    3062062
  • NDL 刊行物分類
    SD0(薬学)
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-375
  • データ提供元
    CJP引用  NDL  NII-ELS  IR  NDL-Digital 
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