Anti-hepatitis C virus activity of geranylgeranylacetone treatment in hepatitis C-infected patients
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- YAMAGUCHI Tohei
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- ICHIKAWA Tatsuki
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- TAKESHITA Shigeyuki
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- TAURA Naota
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- MIYAAKI Hisamitsu
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- MURAOKA Toru
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- SHIBATA Hidetaka
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- HONDA Takuya
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- HAMASAKI Keisuke
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- KATO Yuji
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- TAKESHIMA Fuminao
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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- NAKAO Kazuhiko
- Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University
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Background. Geranylgeranylacetone (GGA), which is an isoprenoid compound, has been used orally as an antiulcer drug in Japan. GGA induces antiviral gene expression by stimulating the formation of interferon-stimulated gene factor 3 in human hepatoma cells. This study verified the anti-hepatitis C virus (HCV) activity of GGA in chronic hepatitis C-infected patients. Methods. The present prospective study included 20 consecutive anti-HCV antibody-positive, HCV-genotype 1b, and chronic gastritis patients who visited Nagasaki University Hospital between January 1999 and December 1999. GGA (150 mg per day, which is the dose generally used for chronic gastritis) was taken orally for four weeks. We evaluated HCV-RNA titers and other clinical parameters at pretreatment, posttreatment, and at the endpoint of the study. Pretreatment was the beginning point of GGA treatment. Posttreatment was the termination point of GGA treatment. The endpoint was the point four weeks after the posttreatment point. Results. All patients completed four weeks of GGA treatment and four weeks of observation. HCV-RNA titers at postpoint were not significantly diminished compared to those at pretreatment. However, HCV-RNA titers were significantly diminished at endtreatment compared to pretreatment. Unfortunately, we did not observe a case with no titer of HCV-RNA. Alanine aminotransferase values and other parameters were not affected by GGA treatment. Conclusion. GGA has anti-HCV activities in chronic hepatitis C-infected patients. In the future, it will be necessary to examine the clinical effectiveness of the combination of treatment with both GGA and interferon in HCV patients.
収録刊行物
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- Acta Medica Nagasakiensia
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Acta Medica Nagasakiensia 57 (1), 1-4, 2012
長崎大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390001204676768256
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- NII論文ID
- 110009226235
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- NII書誌ID
- AA00508430
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- COI
- 1:CAS:528:DC%2BC3sXhsVCgsA%3D%3D
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- HANDLE
- 10069/28545
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- ISSN
- 00016055
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可