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There are strong needs for synthesis of biodegradable polymer in a form of microsphere, because they have found their applications as soft tissue fillers, injectable scaffolds and cell carriers for tissue engineering. Although biodegradable polymer found various applications, there are disadvantages including low cell adhesion due to its hydrophobic surface character. In this study, hydroxyapatite (HAp)-coated biodegradable polymer microsphere was successfully prepared from a Pickering-type emulsion stabilized with HAp nanocrystals without any molecular surfactants. The microspheres showed cell adhesiveness and should be useful for a variety of biomedical applications including implant materials and cell carriers.