超好熱アーキアの新規なNAD(P)依存性アミノ酸脱水素酵素の機能と構造解析

• 米田 一成

  東海大学農学部バイオサイエンス学科

書誌事項

タイトル別名

• Structural and functional analyses of novel NAD(P)-dependent amino acid dehydrogenases from archaea
• チョウコウネツ アーキア ノ シンキ ナ NAD(P)イソンセイ アミノサン ダツスイソ コウソ ノ キノウ ト コウゾウ カイセキ

抄録

NAD(P)-dependent amino acid dehydrogenases are oxidoreductase catalyzing the reversible oxidation of amino acids to their oxo or aldehyde analogs in the presence of NAD or NADP. The enzymes are useful for enzymatic analyses of amino acids, oxo acids and special enzymes, and for the enantiospecific synthesis of L-amino acids and their analogs. In contrast to abundant information available about glutamate, alanine, leucine and phenylalanine dehydrogenases, information about the structure and function of lysine, aspartate, threonine dehydrogenases has been rather limited so far. We have developed the functional and structural analyses of novel types of NAD(P)-dependent amino acid dehydrogenases from hyperthermophilic archaea. The enzymological and structural characteristics of the NAD(P)-dependent amino acid dehydrogenases from archaeal strains are here described.

収録刊行物

• ビタミン

  ビタミン 86 (2), 74-83, 2012

  公益社団法人 日本ビタミン学会

キーワード

• L-amino acid dehydrogenase
• NAD(P)
• crystal structure
• archaea

詳細情報

• CRID: 1390001205701842432
• NII論文ID: 110009419212
• NII書誌ID: AN00207833
• DOI: 10.20632/vso.86.2_74
• ISSN: 2424080X
• ISSN: 0006386X
• NDL書誌ID: 023542634
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023542634
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可