脂溶性ビタミン類による遺伝子発現制御の分子機構に関する研究

• 藤木 亮次

  東京大学分子細胞生物学研究所:科学技術振興機構(JST)さきがけ研究

書誌事項

タイトル別名

• Molecular mechanisms of gene regulations by fat-soluble vitamin
• シ ヨウセイ ビタミンルイ ニ ヨル イデンシ ハツゲン セイギョ ノ ブンシ キコウ ニ カンスル ケンキュウ

抄録

Fat-soluble vitamins A and D are essential for many biological processes in a wide variety of cell types. These actions are exerted by their cognate nuclear receptors (NRs), vitamin A receptor (RAR) and vitamin D receptor (VDR), respectively. Although the molecular basis of NR-mediated transcription has been established, the regulations of the spatiotemporal target genes are not well known. Recently, we have identified the novel co-regulator complexes responsible for NR-mediated transcription. And, we also found that most of them were involved in chromatin reorganization on the promoters. Herein, I report the molecular mechanisms of cell-specific chromatin remodeling in the VDR-mediated transrepression of 25-hydroxyvitamin D_3-1α-hydroxylase [1α(OH)ase] by WSTF, an ATP-dependent chromatin remodeling factor, and RAR-mediated epigenetic regulation through O-linked N-acetylglucosamin signaling during HL60 differentiation. These studies would help our understanding a basic mechanism how tissue-specific regulations of NR target genes were achieved.

収録刊行物

• ビタミン

  ビタミン 86 (3), 142-154, 2012

  公益社団法人 日本ビタミン学会

キーワード

• Vitamin A
• Vitamin D
• nuclear receptor
• transcription
• chromatin remodeling

詳細情報

• CRID: 1390001205700532864
• NII論文ID: 110009426029
• NII書誌ID: AN00207833
• DOI: 10.20632/vso.86.3_142
• ISSN: 2424080X
• ISSN: 0006386X
• NDL書誌ID: 023617620
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023617620
• Web Site: https://search.jamas.or.jp/link/ui/2012220142
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可