Changes in the electroencephalogram caused by intravenous administration of modafinil under sevoflurane anesthesia in rats

• Kano Seiji

  Department of Anesthesiology, Osaka Dental University

• Matsuda Yoshiko

  Department of Anesthesiology, Osaka Dental University

• Kotani Junihciro

  Department of Anesthesiology, Osaka Dental University

抄録

Modafinil, a drug for the treatment of hypersomnia and narcolepsy, activates dopaminergic neurons and histaminergic neurons and inhibits the release of gamma-aminobutyric acid to enhance awakening from natural sleep. However, it is unclear whether modafinil modulates the hypnotic effects of volatile anesthetics. We therefore investigated the effects of intravenous modafinil on the depth of anesthesia in rats under sevoflurane anesthesia by evaluating the spectral edge frequency 95% (SEF95) of the electroencephalogram. Modafinil at various doses did not induce changes in SEF95 in animals anesthetized with a fixed concentration of sevoflurane. The absence of inhibition of the hypnotic effect of sevoflurane suggests that modafinil targets areas in the brain that are not involved in awakening from natural sleep.

収録刊行物

• Journal of Osaka Dental University

  Journal of Osaka Dental University 46 (1), 1-4, 2012

  大阪歯科学会

キーワード

• Modafinil
• Sevoflurane
• Anesthesia
• Electroencephalogram (EEG)
• Spectral edge frequency 95% (SEF95)

詳細情報

• CRID: 1390001204963078784
• NII論文ID: 110009436530
• NII書誌ID: AA00704144
• DOI: 10.18905/jodu.46.1_1
• ISSN: 21896488
• ISSN: 04752058
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可