Influence of decline of occlusal support on bilateral striatal dopamine release in rats

• Kokuba Yukihisa

  Graduate School of Dentistry (Removable Prosthodontics and Occlusion), Osaka Dental University

• Okuda Keiji

  Department of Removable Prosthodontics and Occlusion, Osaka Dental University

• Maeda Teruta

  Department of Removable Prosthodontics and Occlusion, Osaka Dental University Department of Interdisciplinary Dentistry for Postgraduate Trainess, Osaka Dental University

• Okazaki Joji

  Department of Removable Prosthodontics and Occlusion, Osaka Dental University

抄録

Sensory inputs from the periodontal membrane play a role in brain activation and regulate various functions or reflexive feedback. We investigated the possibility of a correlation between striatal function and loss of occlusal support. Eighteen male Sprague-Dawley rats were divided into three groups : the EXT Group (n=6) had all three maxillary molars on both sides extracted ; the EXT-R Group (n=6) had the right maxillary molars extracted ; and the CON Group (n=6) served as a control. Dopamine levels in the bilateral striatum were measured using in vivo microdialysis. Once the extracellular basal concentrations of dopamine were stable, the rats were fed pellets and the food-induced changes in dopamine concentrations were monitored every 10 min for 2 h. In the CON group, feeding induced a significant increase in dopamine concentrations on both sides of the striatum. However in the EXT and EXT-R Groups, no significant increase was observed. This result indicated that even if rats lost occlusal support unilaterally, food-induced dopamine release was impaired bilaterally in the dorsal striatum, and this impairment was associated with occlusal support loss that affected the contralateral striatum.

収録刊行物

• Journal of Osaka Dental University

  Journal of Osaka Dental University 46 (1), 113-120, 2012

  大阪歯科学会

キーワード

• Dopamine
• Occlusal support loss
• Dorsal striatum

詳細情報

• CRID: 1390282679939754880
• NII論文ID: 110009436542
• NII書誌ID: AA00704144
• DOI: 10.18905/jodu.46.1_113
• ISSN: 21896488
• ISSN: 04752058
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可