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- Kokuba Yukihisa
- Graduate School of Dentistry (Removable Prosthodontics and Occlusion), Osaka Dental University
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- Okuda Keiji
- Department of Removable Prosthodontics and Occlusion, Osaka Dental University
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- Maeda Teruta
- Department of Removable Prosthodontics and Occlusion, Osaka Dental University Department of Interdisciplinary Dentistry for Postgraduate Trainess, Osaka Dental University
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- Okazaki Joji
- Department of Removable Prosthodontics and Occlusion, Osaka Dental University
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Sensory inputs from the periodontal membrane play a role in brain activation and regulate various functions or reflexive feedback. We investigated the possibility of a correlation between striatal function and loss of occlusal support. Eighteen male Sprague-Dawley rats were divided into three groups : the EXT Group (n=6) had all three maxillary molars on both sides extracted ; the EXT-R Group (n=6) had the right maxillary molars extracted ; and the CON Group (n=6) served as a control. Dopamine levels in the bilateral striatum were measured using in vivo microdialysis. Once the extracellular basal concentrations of dopamine were stable, the rats were fed pellets and the food-induced changes in dopamine concentrations were monitored every 10 min for 2 h. In the CON group, feeding induced a significant increase in dopamine concentrations on both sides of the striatum. However in the EXT and EXT-R Groups, no significant increase was observed. This result indicated that even if rats lost occlusal support unilaterally, food-induced dopamine release was impaired bilaterally in the dorsal striatum, and this impairment was associated with occlusal support loss that affected the contralateral striatum.
収録刊行物
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- Journal of Osaka Dental University
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Journal of Osaka Dental University 46 (1), 113-120, 2012
大阪歯科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679939754880
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- NII論文ID
- 110009436542
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- NII書誌ID
- AA00704144
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- ISSN
- 21896488
- 04752058
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可