がん細胞情報伝達のダイナミクスとシステムバイオロジー(<特集>疾患の数理モデル(続)) System Biology of Cancer Signal Transduction Dynamics(<Special Topics>Mathematical Model of Disease)

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Here is introduced an example of systems biology study regarding intracellular signal kinetics that determine cell fate. For example, transient and sustained mitogen-activated protein kinase (MAPK) induce proliferation and differentiation of MCF-7 breast cancer cells, respectively. In an effort to delineate the dynamics-oriented cell determination mechanism, we investigate time-course early transcription and intracellular signaling using both experimental and kinetic modeling approaches. One of our studies suggested that AND-gate and layered feedback in the signaling and early transcription network results in a quantitative to qualitative information change in the cell determination process,

収録刊行物

  • 応用数理

    応用数理 22(3), 193-201, 2012

    一般社団法人 日本応用数理学会

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各種コード

  • NII論文ID(NAID)
    110009518432
  • NII書誌ID(NCID)
    AN10288886
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09172270
  • NDL 記事登録ID
    024019034
  • NDL 請求記号
    Z15-726
  • データ提供元
    CJP書誌  NDL  NII-ELS  J-STAGE 
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