Possible miRNA coreguation of target genes in brain regions by both differential miRNA expression and miRNA-targeting-specific promoter methylation

• Y-H.Taguchi

抄録

We computationally reanalysed public domain data set deposited to gene expression omnibus, of mRNA expression, miRNA expression and promoter methylation pattern in four brain regions, i.e., frontal cortex, temporal cortex, pons and cerebellum. Then we found that more than hundreds of both miRNA regulation of target genes and miRNA-targeting-specific promoter methylation are significant on all six pairwise comparisons among the above mentioned four brain regions. We also showed that some of miRNA regulation of target genes are highly correlated with both or either of miRNA-targeting-specific promoter methylation and differential miRNA expression. We concluded that the combinatorial analysis of miRNA regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can figure out brain region specific contribution of miRNAs to brain functions and developments.We computationally reanalysed public domain data set deposited to gene expression omnibus, of mRNA expression, miRNA expression and promoter methylation pattern in four brain regions, i.e., frontal cortex, temporal cortex, pons and cerebellum. Then we found that more than hundreds of both miRNA regulation of target genes and miRNA-targeting-specific promoter methylation are significant on all six pairwise comparisons among the above mentioned four brain regions. We also showed that some of miRNA regulation of target genes are highly correlated with both or either of miRNA-targeting-specific promoter methylation and differential miRNA expression. We concluded that the combinatorial analysis of miRNA regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can figure out brain region specific contribution of miRNAs to brain functions and developments.

収録刊行物

• 研究報告バイオ情報学（BIO）

  研究報告バイオ情報学（BIO） 2013 (6), 1-6, 2013-03-14

詳細情報

• CRID: 1570854177919800704
• NII論文ID: 110009552450
• NII書誌ID: AA12055912
• 本文言語コード: en
• データソース種別:
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