Grifola gargalの投与が高フルクトース食誘発インスリン抵抗性ラットに及ぼす影響

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  • Influences of the Grifola Gargal Extracts on Insulin Resistance Induced by High-Fructose Diet in Rats
  • Grifola gargal ノ トウヨ ガ コウフルクトースショク ユウハツ インスリン テイコウセイ ラット ニ オヨボス エイキョウ

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The purpose of the present study was to evaluate the effects of Grifola gargal (mushroom) extracts on insulin resistance induced by high-fructose diet in rats. Methods: 12 Male rats of Wistar strain aged 7 weeks were divided into 3 groups. There are 1) high-fructose diet group (Fructose 60% content; FRU), 2) high-fructose + Grifola gargal group (FG) and 3) normal diet group (Control). The rats in 3 groups were breeded for 4 weeks under the three conditions described above. Then, after fasting for 16 hours, a sequential euglycemic clamp experiment with two different insulin infusion rates of 6.0 (L-clamp) and 30.0 (H-clamp) mU/kgBW/minwas performed. Results: The serum glucose concentration in each rat was maintained at the level of basal blood glucose concentrations in the experiment. The glucose infusion rate (GIR) was assumed to be an index of the action of insulin for 60-90 and 150-180 minutes. As a result, the FRU group and FG group markedly reduced GIRs in L-clamp experiment compared with Control group. However, a significant difference was not able to be confirmed between FG and FRU groups. Consequently, in L-clamp and H-clamp, GIR in FG group were increased by Grifola gargal extracts compared with FRU group, and reached the almost same levels as in Control group. Conclusion: It was suggested that the administration of Grifola gargal extracts affect insulin sensitivity, and insulin responsiveness.

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