うつ病の病態はどこまで明らかになったか?("うつ"に挑む実験心理学,2011年度 第2回フォーラム)

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  • Present findings for the pathophysiology of depression(Forum: Current approaches to depression in experimental psychology)
  • 講演論文 うつ病の病態はとこまで明らかになったか?
  • コウエン ロンブン ウツビョウ ノ ビョウタイ ワ ト コ マデ アキラカ ニ ナッタ カ?

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Depression is a general term of a broad syndrome with various clinical symptoms such as depressive mood, diminished interest, agitation, insomnia, and decreased appetite. Although dysregulation of hypothalamus-pituitary-adrenal system and abnormality of monoaminergic neuron have been pointed out since 1950', it has not yet reached a conclusion whether it is a cause of depression, a result of depression, or an accompanied change of depression even today. In this article, present findings for the pathophysiology of depression are reviewed from a wide viewpoint including animal model studies, genetic studies, neuroendocrinological studies, neurochemical and molecular biological studies and brain imaging studies.

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