Inhibition of P-glycoprotein by multi-walled carbon nanotubes in Caco-2 cells

• CHEN Xiao

  Hokkaido Univ.

• WATARI Fumio

  Hokkaido Univ.

抄録

CaCo-2 cells with constitutive P-glycoprotein (Pgp) expression were exposed to multiwalled carbon nanotubes (MWCNTs). Subsequent flow cytometry showed decreased efflux of intracellular Pgp substrates. RT-PCR and Western blotting analysis showed reduced Pgp mRNA and protein respectively. We conclude that MWCNTs could decrease Pgp expression both at transcriptional and translational level, and thereby reducing Pgp-mediated drug transport.

収録刊行物

• 日本歯科理工学会誌 = The journal of the Japanese Society for Dental Materials and Devices

  日本歯科理工学会誌 = The journal of the Japanese Society for Dental Materials and Devices 32 (2), 95-, 2013-03-25

  一般社団法人日本歯科理工学会

詳細情報

• CRID: 1573105977740034944
• NII論文ID: 110009596394
• NII書誌ID: AA12452694
• ISSN: 18844421
• Web Site: https://search.jamas.or.jp/link/ui/2014043082
• 本文言語コード: en
• データソース種別:
  • CiNii Articles