テラピア由来コラーゲンのマウスES細胞の3次元スキャフォードとしての可能性

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  • Study of collagen derived from tilapia scales as three-dimensional scaffold of mouse ES cell differentiation

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Three-dimensional culture is required to regenerate tissues and organs of interest through cell differentiation. In the present study, we examined whether type I collagen, extracted from the scales of tilapia inhabiting tropical and subtropical areas, can be used as a scaffold for mouse ES cells. As a result, it had no effect on ES-D3 cell differentiation as compared with conventional porcine collagen. In a previous study, salmon collagen could not withstand long-term culture. Thus, the collagen obtained from tilapia, featuring a high temperature, is useful as a scaffold for mouse ES cell differentiation. The collagen extracted from the scales of tilapia is likely to serve as a promising scaffold for tissue regeneration.

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