Cross-talk between Bone Marrow and Tissue Injury : Novel Regenerative Therapy for Severely Damaged Tissues by Mobilizing Bone Marrow Mesenchymal Stem Cells in Vivo

• Tamai, Katsuto

• Kaneda, Yasufumi

抄録

group box 1 （HMGB1）, which mobilizes a sub-population of non-hematopoietic cells from bone marrow into the circulation to repair skin and restore Col 7 expression. These bone marrow-derived epithelial stem/progenitor cells are derived from a lineage-negative, platelet-derived growth factor alpha-positive mesenchymal stem cell pool in bone marrow, which represents less than 0.3% of the total bone marrow cell population. In addition, systemic administration of HMGB1 to wounded wild-type mice leads to faster wound healing with recruitment of these bone marrow cells to the wounded skin. This study identifies a suitable cell population for cell therapy approaches in individuals with RDEB, but also has broader implications for clinical medicine in identifying a means of mobilizing and recruiting a key population of bone marrow cells germane to tissue repair.

弘前医学. 64(Suppl.), 2013, p.S1-S5

収録刊行物

• 弘前医学

  弘前医学 64 (Supplement), S1-S5, 2013-04-02

  弘前大学大学院医学研究科・弘前医学会

キーワード

• 医学
• mesenchymal stem cell
• high mobility group box 1
• epidermolysis bullosa

詳細情報

• CRID: 1050001201685696000
• NII論文ID: 110009614309
• NII書誌ID: AN00211444
• ISSN: 04391721
• HANDLE: 10129/4859
• NDL書誌ID: 024696437
• Web Site: https://hirosaki.repo.nii.ac.jp/records/3770
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024696437
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • NDL
  • CiNii Articles